|
|
protein_tyrosine_phosphate + H2O <=> phosphate + a_[protein]-L-tyrosine
|
3.1.3.48
protein-tyrosine-phosphatase
|
–
|
|
|
BRENDA:
BR11748;
BS425091
KEGG:
R02585
MetaCyc:
PROTEIN-TYROSINE-PHOSPHATASE-RXN
SABIO-RK:
2491
|
|
|
|
a_[protein]-L-tyrosine + O2 + H2O <=> [protein]-(S)-2-amino-6-oxohexanoate + NH3 + H2O2
|
1.4.3.13
protein-lysine 6-oxidase
|
–
|
|
|
BRENDA:
BR36875
KEGG:
R04239
MetaCyc:
PROTEIN-LYSINE-6-OXIDASE-RXN
|
|
|
|
a_[protein]-L-tyrosine + acetyl-CoA <=> [protein]-N6-acetyl-L-lysine + CoA + H+
|
2.3.1
2.3.1.48
histone acetyltransferase
|
–
–
|
|
|
BRENDA:
BR44049
MetaCyc:
RXN0-7160
|
|
|
|
ATP + a_[protein]-L-tyrosine <=> ADP + protein_tyrosine_phosphate + H+
|
2.7.1.112
protein-tyrosine kinase
2.7.10.1
receptor protein-tyrosine kinase
2.7.10.2
non-specific protein-tyrosine kinase
2.7.10.a
2.7.11.1
non-specific serine/threonine protein kinase
2.7.12.1
dual-specificity kinase
2.7.12.2
mitogen-activated protein kinase kinase
|
–
–
–
–
–
–
–
|
|
|
BRENDA:
BR44293;
BR48589;
BS398745
KEGG:
R02584
MetaCyc:
2.7.10.1-RXN
SABIO-RK:
2490
|
|
|
|
[protein]-N6-acetyl-L-lysine + NAD+ + H2O <=> a_[protein]-L-tyrosine + 2''''-O-acetyl-ADP-ribose + nicotinamide
|
2.3.1.286
protein acetyllysine N-acetyltransferase
2.3.1.B43
|
–
–
|
K
|
|
BRENDA:
BR51226
KEGG:
R10634
MetaCyc:
RXN0-7078
|
|
|
|
a_[protein]-L-tyrosine + 2-oxoglutarate + O2 <=> a_[protein]-(3S)-3-hydroxy-L-lysine + succinate + CO2
|
1.14.11.63
peptidyl-lysine (3S)-dioxygenase
|
–
|
|
|
BRENDA:
BR52668;
BS448336
KEGG:
R12315
MetaCyc:
RXN-20177
|
|
|
|
ATP + [prokaryotic_ubiquitin-like_protein]-L-glutamate + a_[protein]-L-tyrosine <=> ADP + phosphate + N6-([prokaryotic_ubiquitin-like_protein]-gamma-L-glutamyl)-[protein]-L-lysine
|
6.3.1.19
prokaryotic ubiquitin-like protein ligase
|
–
|
|
|
BRENDA:
BR51255
KEGG:
R11207
|
|
|
|
N6-([prokaryotic_ubiquitin-like_protein]-gamma-L-glutamyl)-[protein]-L-lysine + H2O <=> [prokaryotic_ubiquitin-like_protein]-L-glutamate + a_[protein]-L-tyrosine
|
3.5.1.119
Pup amidohydrolase
|
–
|
|
|
BRENDA:
BS430450
KEGG:
R11208
|
|
|
|
L-glutaminyl-peptide + a_[protein]-L-tyrosine <=> protein_with_an_N6-(gamma-glutamyl)-L-lysine_crosslink + NH3
|
2.3.2.13
protein-glutamine gamma-glutamyltransferase
|
–
|
|
|
MetaCyc:
2.3.2.13-RXN
|
|
|
|
[protein]-N6-monoubiquitinyl-L-lysine + H2O <=> a_[protein]-L-tyrosine + [ubiquitin]_C-terminal_glycine
|
3.4.19.12
ubiquitinyl hydrolase 1
|
–
|
|
|
MetaCyc:
3.4.19.12-RXN
|
|
|
|
a_[protein]-L-tyrosine + 3''-phosphoadenylyl-sulfate <=> adenosine_3,5''-bisphosphate + protein_L-tyrosine-O-sulfate + H+
|
2.8.2.20
protein-tyrosine sulfotransferase
|
–
|
|
|
MetaCyc:
PROTEIN-TYROSINE-SULFOTRANSFERASE-RXN
|
|
|
|
[HECT-type_E3_ubiquitin_transferase]-S-ubiquitinyl-L-cysteine + a_[protein]-L-tyrosine <=> [HECT-type_E3_ubiquitin_transferase]-L-cysteine + [protein]-N6-monoubiquitinyl-L-lysine + H+
|
2.3.2.26
HECT-type E3 ubiquitin transferase
|
–
|
M
|
|
MetaCyc:
RXN-15560
|
|
|
|
[E2_ubiquitin-conjugating_enzyme]-S-ubiquitinyl-L-cysteine + a_[protein]-L-tyrosine <=> [E2_ubiquitin-conjugating_enzyme]-L-cysteine + [protein]-N6-monoubiquitinyl-L-lysine + H+
|
2.3.2.27
RING-type E3 ubiquitin transferase
|
–
|
M
|
|
MetaCyc:
RXN-15561
|
|
|
|
[E1_ubiquitin-activating_enzyme]-S-ubiquitinyl-L-cysteine + a_[protein]-L-tyrosine <=> [E1_ubiquitin-activating_enzyme]-L-cysteine + [protein]-N6-monoubiquitinyl-L-lysine + H+
|
2.3.2.24
(E3-independent) E2 ubiquitin-conjugating enzyme
|
–
|
|
|
MetaCyc:
RXN-16302
|
|
|
|
[(E3-independent)_E2_ubiquitin-conjugating_enzyme]-S-ubiquitinyl-L-cysteine + a_[protein]-L-tyrosine <=> [protein]-N6-monoubiquitinyl-L-lysine + [(E3-independent)_E2_ubiquitin-conjugating_enzyme]-L-cysteine + H+
|
2.3.2.24
(E3-independent) E2 ubiquitin-conjugating enzyme
|
–
|
M
|
|
MetaCyc:
RXN-16313
|
|
|
|
N6-SAMP-[protein]-L-lysine + H2O <=> a_[protein]-L-tyrosine + [SAMP]_C-terminal_glycine
|
3.4.19.15
desampylase
|
–
|
|
|
MetaCyc:
RXN-16315
|
|
|
|
a_[protein]-L-tyrosine + protein <=> copper-complexed_cysteinyltyrosyl_radical_cofactor
|
not assigned
|
–
|
|
|
MetaCyc:
RXN-16451
|
|
|
|
a_[protein]-L-tyrosine + O2 <=> topaquinone + H2O2 + H+
|
not assigned
|
–
|
|
|
MetaCyc:
RXN-16454
|
|
|
|
ATP + [prokaryotic_ubiquitin-like_protein]_C-terminal_L-glutamate + a_[protein]-L-tyrosine <=> ADP + phosphate + N6-([prokaryotic_ubiquitin-like_protein]-gamma-L-glutamyl)-[protein]-L-lysine + H+
|
6.3.1.19
prokaryotic ubiquitin-like protein ligase
|
–
|
M
|
|
MetaCyc:
RXN-16707
|
|
|
|
N6-([prokaryotic_ubiquitin-like_protein]-gamma-L-glutamyl)-[protein]-L-lysine + H2O <=> [prokaryotic_ubiquitin-like_protein]_C-terminal_L-glutamate + a_[protein]-L-tyrosine
|
3.4.99.M1
|
–
|
M
|
|
MetaCyc:
RXN-16708
|
|
|
|
methylglyoxal + a_[protein]-L-tyrosine <=> an_N6-(1-hydroxy-2-oxopropyl)-[protein]-L-lysine + H+
|
not assigned
|
–
|
|
|
MetaCyc:
RXN-17631
|
|
|
|
an_N6-(1-hydroxy-2-oxopropyl)-[protein]-L-lysine + H2O <=> a_[protein]-L-tyrosine + D-lactate
|
3.5.1.124
protein deglycase
|
–
|
|
|
MetaCyc:
RXN-17632
|
|
|
|
S-[SAMP]-[E1_SAMP-activating_enzyme]-L-cysteine + a_[protein]-L-tyrosine <=> N6-SAMP-[protein]-L-lysine + [E1_SAMP-activating_enzyme]-L-cysteine + H+
|
2.3.2
|
–
|
M
|
|
MetaCyc:
RXN-18692
|
|
|
|
[protein]-N6-acetyl-L-lysine + H2O <=> a_[protein]-L-tyrosine + acetate
|
3.5.1
|
–
|
|
|
MetaCyc:
RXN-18952
|
|
|
|
[RBR-type_E3_ubiquitin_transferase]-S-ubiquitinyl-L-cysteine + a_[protein]-L-tyrosine <=> [RBR-type_E3_ubiquitin_transferase]-L-cysteine + [protein]-N6-monoubiquitinyl-L-lysine + H+
|
not assigned
|
–
|
|
|
MetaCyc:
RXN-19354
|
|
|
|
[E2_ubiquitin-conjugating_enzyme]-S-ubiquitinyl-L-cysteine + a_[protein]-L-tyrosine <=> [E2_ubiquitin-conjugating_enzyme]-L-cysteine + [protein]-N6-monoubiquitinyl-L-lysine + H+
|
2.3.2.31
RBR-type E3 ubiquitin transferase
|
–
|
|
|
MetaCyc:
RXN-19355
|
|
|
|
[protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + H2O <=> a_[protein]-L-tyrosine + 2''''-O-acetyl-ADP-ribose
|
not assigned
|
–
|
|
|
MetaCyc:
RXN-19920
|
|
|
|
(8S)-8-amino-7-oxononanoate + a_[protein]-L-tyrosine + CO2 <=> (7R,8S)-8-amino-7-(carboxyamino)nonanoate + [protein]-(S)-2-amino-6-oxohexanoate + H+
|
2.6.1.al
|
–
|
|
|
MetaCyc:
RXN-21306
|
|
|
|
(8S)-8-amino-7-oxononanoate + a_[protein]-L-tyrosine + NADPH <=> [protein]-N6-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysine + H2O + NADP+
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-21307
|
|
|
|
(8S)-8-amino-7-oxononanoate + a_[protein]-L-tyrosine + NADH <=> [protein]-N6-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysine + H2O + NAD+
|
not assigned
|
–
|
|
|
MetaCyc:
RXN-21307_WOP
|
|
|
|
[protein]_N6-methyl-L-lysine + 2-oxoglutarate + O2 <=> a_[protein]-L-tyrosine + succinate + formaldehyde + CO2
|
1.14.11
|
–
|
|
|
MetaCyc:
RXN-8661
|
|
|
|
protein_N6-methyl-L-lysine + 2-oxoglutarate + O2 <=> a_[protein]-L-tyrosine + succinate + formaldehyde + CO2
|
1.14.11.27
[histone H3]-dimethyl-L-lysine36 demethylase
1.14.11.65
[histone H3]-dimethyl-L-lysine9 demethylase
|
–
–
|
|
|
BRENDA:
BS383337
|
|
|
|
S-adenosyl-L-methionine + a_[protein]-L-tyrosine <=> S-adenosyl-L-homocysteine + [protein]_N6-methyl-L-lysine
|
2.1.1.B112
|
–
|
|
|
BRENDA:
BR50863
|
|
|
|
[protein]-N6-acetyl-L-lysine + NAD+ + H2O <=> a_[protein]-L-tyrosine + 2''''-O-acetyl-ADP-D-ribose + nicotinamide
|
2.3.1.286
protein acetyllysine N-acetyltransferase
|
–
|
|
|
BRENDA:
BR51227
|
|
|
|
NAD+ + [protein]-N6-acyl-L-lysine <=> nicotinamide + a_[protein]-L-tyrosine + 2''-O-acyl-ADP-ribose
|
2.3.1.286
protein acetyllysine N-acetyltransferase
|
–
|
|
|
BRENDA:
BS436528
|
|
|
|
NAD+ + [protein]-N6-palmitoyl-L-lysine <=> nicotinamide + a_[protein]-L-tyrosine + 2''-O-palmitoyl-ADP_ribose
|
2.3.1.B41
|
–
|
|
|
BRENDA:
BR51228
|
|
|
|
NAD+ + [protein]-N6-succinyl-L-lysine <=> nicotinamide + a_[protein]-L-tyrosine + 2''-O-succinyl-ADP-ribose
|
2.3.1.B43
|
–
|
|
|
BRENDA:
BR51225
|
|
|
|
NAD+ + [chicken_erythrocyte_histone]-N6-acetyl-L-lysine <=> nicotinamide + a_[protein]-L-tyrosine + O-acetyl-ADP-ribose
|
2.3.1.286
protein acetyllysine N-acetyltransferase
|
–
|
|
|
BRENDA:
BS429326
|
|
|
|
NAD+ + [protein]-N6-malonyl-L-lysine <=> nicotinamide + a_[protein]-L-tyrosine + 2''-O-malonyl-ADP-ribose
|
2.3.1.B43
|
–
|
|
|
BRENDA:
BS429341
|
|
|
|
NAD+ + [protein]-N6-myristoyl-L-lysine <=> nicotinamide + a_[protein]-L-tyrosine + 2''-O-myristoyl-ADP-ribose
|
2.3.1.286
protein acetyllysine N-acetyltransferase
|
–
|
|
|
BRENDA:
BS436529
|
|
|
|
N6-SAMP1-[protein]-L-lysine + H2O <=> SAMP1 + a_[protein]-L-tyrosine
|
3.4.19.15
desampylase
|
–
|
|
|
BRENDA:
BS430452
|
|
|
|
N6-SAMP2-[protein]-L-lysine + H2O <=> SAMP2 + a_[protein]-L-tyrosine
|
3.4.19.15
desampylase
|
–
|
|
|
BRENDA:
BS430453
|
|
|
|
[protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + H2O <=> a_[protein]-L-tyrosine + 2''''-O-acetyl-ADP-D-ribose
|
2.3.1.286
protein acetyllysine N-acetyltransferase
|
–
|
|
|
BRENDA:
BR52736
|
|
|
|
ATP + [prokaryotic_ubiquitin-like_protein]-L-glutamate + a_[protein]-L-tyrosine <=> ADP + phosphate + N6-[[prokaryotic_ubiquitin-like_protein]-L-glutamate]-[[protein]-L-lysine]
|
6.3.1.19
prokaryotic ubiquitin-like protein ligase
|
–
|
|
|
BRENDA:
BS429202
|
|
|
|
ATP + [SAMP1]-Gly-Gly + a_[protein]-L-tyrosine <=> AMP + diphosphate + N6-[[SAMP1]-Gly-Gly]-[[protein]-L-lysine]
|
6.2.1.55
E1 SAMP-activating enzyme
|
–
|
|
|
BRENDA:
BS429203
|
|
|
|
ATP + [SAMP2]-Gly-Gly + a_[protein]-L-tyrosine <=> AMP + diphosphate + N6-[[SAMP2]-Gly-Gly]-[[protein]-L-lysine]
|
6.2.1.55
E1 SAMP-activating enzyme
|
–
|
|
|
BRENDA:
BS429204
|
|
|
|
ATP + [SAMP3]-Gly-Gly + a_[protein]-L-tyrosine <=> AMP + diphosphate + N6-[[SAMP3]-Gly-Gly]-[[protein]-L-lysine]
|
6.2.1.55
E1 SAMP-activating enzyme
|
–
|
|
|
BRENDA:
BS429205
|
|